Clinical Guideline Intelligence

The Safe Second Look for Oncology.

POLI8 is an audit-grade, AI-powered verification layer for oncology multidisciplinary tumor board recommendations. Over 90% concordance in pilot operation since 2025.

POLI8 Trace Fall #4721
Enzalutamid ↔ S3-Prostata-CA §6.2.1
Abirateron ↔ EAU abw. Empfehlung EAU 2024
Darolutamid ↔ NCCN konform PRO-3.1
Off-Label: PARP-Inhibitor BRCA+ / HRD
4 Leitlinien geprüft v2024.3 · 3.2s
≈ 400,000
cancer deaths per year in Europe
GLOBOCAN 2022
+24%
projected rise in EU cancer cases by 2035 with constant specialist shortage
European Cancer Statistics
Up to 46%
Therapy deviations from guidelines (variability due to caution in documentation)
Oncology MTB literature
< 3 min
decision time per complex case in tumor board
Munro et al., BJU Int 2023

The problem

A cognitive crisis in the gold standard.

Oncology has the highest publication rate of all medical disciplines. Over 100,000 new studies per year. Guidelines update in 12 to 18 month cycles. No human can keep up.

This is not a competence problem.

It is a capacity problem.

POLI8 is the answer.

The solution

Three steps. One referenced, audit-grade recommendation.

01 · INGEST

Structured input

Falldaten fließen über HL7 FHIR R4 aus dem KIS und der Tumordokumentation. Direkte I

02 · VERIFY

Constrained RAG, version-pinned

Therapieoptionen werden gegen den aktuellen, versionsgepinnten Leitlinienkorpus gepr

03 · DOCUMENT

Audit-grade record

Das Ergebnis ist ein Eintrag mit Quellenangabe (Leitlinie, Abschnitt, Versionsdatum,

Evidenced, not claimed

Three pieces of evidence that carry trust.

90%

Clinical concordance

Over 90% agreement with board decision.

From ongoing pilot operation at the Swiss Urology Competence Center: over 90% concordance with guideline recommendations.

ESMO ELCAP 2025

Scientific anchoring

ESMO ELCAP 2025-compliant.

We follow the framework that ESMO presented in the Annals of Oncology in October 2025 for AI-assisted guideline verification.

Annals of Oncology ↗
3

Binding intent

Three Letters of Intent in place.

Three institutions from the DACH region have formally declared their intention to pilot POLI8 (Letters of Intent).

What sets us apart

Three properties no one else combines.

Workflow, not search engine

In the tumor board, not next to it.

OpenEvidence, ChatGPT Health, Claude for Life Science are search and synthesis tools. They do not verify guideline concordance and provide no audit trail.

Locally compliant, not US-centric

S3, EAU, NCCN, AUA · all four.

US platforms know NCCN. POLI8 additionally understands the international and European guideline landscape that is critical for EU compliance.

White box, not black box

Every recommendation is traceable.

Navify and ArteraAI deliver scores without justification. POLI8 annotates every recommendation with guideline source, evidence level, and reasoning trace.

Speak to the team.

Clinical pilots and investor enquiries.